**About the role**

You strongly support our mass spectrometry team in the day-to-day operation of our MS facility, with a particular focus on hydrogen-deuterium exchange mass spectrometry (HDX-MS) but also intact mass and other standard LC-MS analyses. With your fast, accurate and well-organized way of working you ensure and substantially increase the throughput of our analytical pipeline. You prepare samples, execute MS analyses on LC-MS and HDX-MS workflows under the guidance of our Principal Scientist Mass Spectrometry, and contribute your experience in organizing and maintaining laboratory workflows to ensure smoothly running lab operations. Candidates need to bring prior experience in mass spectrometry; however, not all activities described must already have been performed in a previous role. We value a strong foundation and the motivation to learn, with opportunities to grow and build further expertise on the job. You work in a highly collaborative, team-oriented and fast-paced startup environment with a strong commitment to deliver and in ways that cut across traditional industry boundaries.

**What you'll do**

- Help setting up, maintain and run the Mass Spectrometry facility, ensuring instruments, consumables and shared resources are kept in optimal working condition.
- Support the design, planning and execution of HDX-MS experiments on single proteins and protein–protein or protein–ligand complexes related to cancer, neurodegenerative and other diseases.
- Perform sample preparation and execution of MS analyses under the guidance of our Principal Scientist, with a particular focus on HDX-MS experiments, but also intact mass, ion mobility and standard LC-MS analyses.
- Operate instrumentation in the mass spec facility, including handling of the LC system, stopped-flow, robotic HDX devices and the mass spectrometer.
- Perform basic data processing and quality control of HDX-MS, intact mass and other LC-MS dataset, and report results to our Principal Scientist.
- Ensure that experimental data, protocols and observations are accurately documented in the electronic lab notebook (ELN) daily.
- Keep the lab inventory updated: order, receive and track consumables, reagents, columns, solvents and spare parts for the MS facility, and manage stocks to avoid downtime.
- Participate in the preparation, revision and maintenance of Standard Operating Procedures (SOPs) for sample preparation, instrument operation and routine analytical workflows.
- Perform routine instrument maintenance, basic troubleshooting and scheduled calibration; coordinate with engineers and vendors for preventive maintenance and repairs.
- Contribute to the general operation, organization, cleanliness and safety of the MS laboratory facilities, including handling of chemicals, solvents and biological samples.
- Operate and maintain auxiliary lab equipment such as pipetting robots, centrifuges, balances, pH meters and -80 °C freezers.
- Help in establishing and maintaining good laboratory practices and ensure compliance with health, safety and environmental standards.
- Share responsibility within the team in terms of defining objectives and meeting pre-set deadlines and manage multiple time-dependent operations in parallel.
- Carry out any other relevant duties as may reasonably be associated with the position, and which may be required from time to time.

**What you bring to the team**

- Vocational education as lab technician, Bachelor or similar degree in Biochemistry, Chemistry, Biotechnology, Biology or related science, plus at least 2–3 years of related laboratory experience, preferably in an industry or core-facility setting.
- Previous experience with Mass Spectrometry applications is a must.
- Demonstrated hands-on experience in a mass spectrometry laboratory, with practical knowledge of sample preparation for protein MS analyses.
- Experience with LC-MS instrumentation and MS-related software for operating the instruments and for basic data processing and evaluation.
- Hands-on experience with HDX-MS workflows (e.g., automated HDX systems, peptic digestion, low-temperature/low-pH handling) is a strong plus.
- Experience with intact mass analyses is a plus.
- Solid understanding of chromatographic principles and of the handling of biological samples and buffers.
- Highly proactive mindset to solve technical problems and to support instrument troubleshooting and maintenance.
- Strong scientific and organizational skills with great attention to detail, accuracy and reproducibility.
- Experience with ELN systems and proficiency in standard office software (MS Office) for data evaluation, reporting and presentation.
- You can work independently but are also a great team player with excellent communication and interpersonal skills.
- Integrity, enthusiasm, motivation, flexibility, confidence, and good collaboration skills.
- An open mindset and the willingness to learn new techniques and instruments are highly valued.
- Fluency in spoken and written English is mandatory. Fluency in Italian is a plus.



##### **Company**

Peptone Switzerland AG

##### **Location**

Bellinzona, Switzerland

##### **Categories**

Analytical tests & screening

Biochip/biosensors

Bioinformatics

Cell culture, cell technology

Laboratory equipment & devices

Medical devices/technologies

Platform technologies

##### **Contact information**

Marta Fiocco

carreers@peptone.io